Leptin replacement has been shown to result in resumption in ovulation, increase in LH and oestradiol levels in blood and increase in follicular diameter and number in women with hypothalamic amenorrhea and replacement of leptin in deficient individuals has led to the successful treatment of hypogonadism by gonadotropin secretion and the restoration of puberty and fertility [48]. Here, PLOD1 is linked to hypogonadism.