As we could not examine adipose tissue specimens as part of this study it is unclear if the upregulation of expression of LEP and LEPR observed in white blood cells from this Galactosaemia cohort with the existence of decreased circulating leptin levels relates to altered transcriptional regulatory pathways, inflammatory mediators, or adaptive changes directly affecting leptin signalling molecules such as Suppressor of Cytokine Signaling 3 (SOCS3) [56]. The gene discussed is SOCS3; the disease is galactosemia.