It has also been reported that JAG1 overexpression by bystander and adjacent tumor cells leads to Notch1 activation and promotes cell growth in Hodgkin’s and anaplastic large cell lymphoma [31], suggesting that high expression of JAG1 might have a role in the activation of Notch1 in HTLV-1-induced leukemia. The gene discussed is NOTCH1; the disease is anaplastic large cell lymphoma.