LEP and asthma: This a priori conjecture is based on the observations that (i) leptin is associated with asthma [29], presumably through inducing oxidative stress and inflammation in the airways [30, 31], (ii) leptin exhibits a strong sex-related dimorphism, as females have higher concentrations compared to males [31, 32], and (iii) leptin mRNA expression is modulated in response to acetaminophen exposure [33, 34].