The nanobody B10AP grafted with Gd(DOTA) shows detection towards amyloid fibers of islet amyloid polypeptide (IAPP) and fibers of transthyretin (TTR), which are involved in type 2 diabetes and polyneuropathy, respectively, and has great affinities with KD values in the 10-nM range in vitro [16]. The gene discussed is TTR; the disease is polyneuropathy.