CD4 and systemic sclerosis: The results revealed that, while no significant differences in both groups (≤6 years and >6 years) were found for HCMV-specific CD4+ T cell responses (Figure 4a), SSc patients with a longer disease duration (>6 years) had a significantly increased HCMV-specific CD8+ T cell responses vs. patients with a disease duration ≤6 years (medians: 9.27% and 1.73% of total CD8+ T cells respectively, p = 0.02) (Figure 4b).