STAT3 and neoplasm: Aberrant STAT3 signaling was experimentally linked to both tumor initiation and progression by inducing a wide range of intracellular processes, such as inhibiting apoptosis or inducing cell proliferation, angiogenesis, invasion, and metabolism changes, as well as extracellular ones, such as extracellular matrix (ECM) remodeling, angiogenesis, and immunity [1,4].