Transgenic mice, obtained by the over-expression of mutated forms of human genes associated with AD such as the amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) or apolipoprotein E (ApoE), are the most useful models, since the neuropathology elicited by these animals is analogous to that observed in human AD, and furthermore, biochemical routes in humans and rodents are very similar [17]. Here, PSEN1 is linked to Alzheimer disease.