The proteins involved in neurodegenerative diseases such as DRP1 (dynamin related protein 1) and MFN2 (mitofusin 2) are enriched in MAMs [130,131] and the perturbation of mitochondria-ER contacts has been described in neurodegenerative disorders, including PD, AD and ALS [132]. This evidence concerns the gene MFN2 and Alzheimer disease.