In Hodgkin lymphoma (HL), in fact, identification of specific genetic features for disease monitoring is still challenging, since malignant cells are usually very rare in bulk tissue (<5%), though some recurrent aberrations have been identified (e.g., IGH rearrangements, mutations in TNFAIP3, XPO1, NFκB, JAK/STAT genes) [23,24]. This evidence concerns the gene NFKB1 and Hodgkins lymphoma.