Alloactivation of MAIT cells due to their inherent cross‐reactivity via a TCR restricted to the highly evolutionarily conserved MR1 would require the presentation of bacterial antigen in the context of infection or contamination; however, bystander TCR‐independent activation may occur in an inflammatory environment and play a role in mediation and augmentation of rejection or organ dysfunction post‐transplant. This evidence concerns the gene MR1 and infection.