ADAM12 and preeclampsia: Several of the THE1B-associated genes in our study that are expressed at significantly higher levels in human relative to mouse placenta have been previously implicated in human placental function, including the regulation of birth timing (CGA [54], CRH [1]) and adverse pregnancy outcomes like preeclampsia (ADAM12, PGF [55], ZFAT [56], TUSC3 [57]) and recurrent miscarriage (ADM [58]).