Recombinant GH therapy in patients with a short stature with GHD and other disorders that do not fit the definition of classic GH deficiency, such as intrauterine growth restriction, healthy children with a short stature or chronic renal disease (CKD), has been reported to have a beneficial effect on growth with no adverse effects on renal function [28–30]. The gene discussed is GH1; the disease is chronic kidney disease.