SIRT1 and AMPK are well‐known metabolic regulators activated in response to metabolic challenges, including the decrease in cell energy levels (e.g., during starvation/fasting).23, 24 During cholestasis, disruption of the flux of bile acids to the intestine contributes to deficient lipid absorption that overall impacts on the metabolic/energy status of the liver. This evidence concerns the gene SIRT1 and cholestasis.