NR1H4 and cholestasis: This is supported by previous studies,11, 35, 37 including work from Wagner et al., showing that whole‐body FXR‐deficient mice had lower intrabiliary pressure after BDL overall relating to less bile infarcts and attenuated liver damage after BDL.11 Similarly, we found reduced ductular reaction at early stages of cholestasis in both SIRToe and SIRT1hep–/– mice, though differences were not statistically significant in the latter and became comparable to WT mice at later stages after BDL.