Supporting this, we demonstrated that SIRT1 overexpression leads to impaired liver regeneration after partial hepatectomy, which associated with disturbances in bile acid homeostasis, including reduced FXR signaling, increased synthesis and accumulation of toxic bile acids in the liver.16 Overall, these results led us to hypothesise that SIRT1 may play a role during CLD. This evidence concerns the gene SIRT1 and congenital secretory chloride diarrhea 1.