Numerous studies have measured the associations between anti‐Ascaris IgE and asthma symptoms, generally showing strong positive associations with wheeze, asthma and bronchial hyper‐reactivity.48, 49, 50, 51, 52 In cross‐sectional studies in Ecuador, we have observed strong associations between anti‐Ascaris IgE and wheeze symptoms among schoolchildren living in rural and urban areas of Esmeraldas Province.53, 54 Among rural schoolchildren, the presence of anti‐Ascaris IgE explained approximately 50% of wheeze symptoms and 30% of wheeze53 and asthma54 in the City of Esmeraldas. This evidence concerns the gene IGHE and asthma.