We and several other groups have shown that tumor cells and associated stromal cells express adrenergic receptors and their signaling induces tumor cell proliferation and resistance to apoptosis, production of vascular endothelial growth factor (VEGF), epithelial–mesenchymal transition (EMT)-associated changes which facilitate metastasis, and induction of the angiogenic switch in endothelial cells [3–7]. Here, VEGFA is linked to neoplasm.