For example, mice deficient in Ndst1 (N-deacetylase sulfotransferase isoenzyme 1) die neonatally due to several defects in which defective sonic hedgehog (Shh) signaling is implicated [11, 12]; mice deficient in Hs2st (heparan sulfate 2-O sulfotransferase) or Glce (glucuronic acid epimerase) display renal agenesis [13, 14], whereas mice deficient in Hs6st1 (heparan sulfate 6-O sulfotransferase isozyme 1) show aberrant signaling of VEGF (vascular endothelial growth factor) and impaired lung development [15]. The gene discussed is GLCE; the disease is renal agenesis.