PNPLA3 and metabolic dysfunction-associated steatohepatitis: Carriage of a genetic variant in TM6SF2 (rs58542926 c.449 C>T, p.E167K) on chromosome 19 (19p13.11) has been reported to correlate with steatosis and advanced fibrosis in NASH patients [24, 25], independently of diabetes, obesity, or PNPLA3 genotype.