This review will focus on the common roles of splicing in diseases of erythropoiesis with an emphasis on recent insights into the transcriptomes of developing RBCs, the effects of splicing factor mutations that drive myelodysplastic syndromes (MDSs), and current efforts to restore normal globin expression in thalassemias using CRISPR/Cas-mediated genome editing. The gene discussed is SLU7; the disease is myelodysplastic syndrome.