Less than 5% of all CAs are familial adenomas representing rare tumor manifestations in various hereditary endocrine syndromes—multiple endocrine neoplasia 1 (MEN1), MEN4, Carney complex (CNC), and DICER1 syndrome—or in familial isolated pituitary adenomas (FIPAs)4,8. This evidence concerns the gene CDKN1B and Carney complex.