p53 also plays an important role in DBA pathophysiology, with p53 activation and the altered expression of its targets (p21, Bax, noxa) having been documented in erythroid cells from affected patients and in CD34+ cord blood erythroid progenitors following lentiviral transfection with various shRNAs targeting RPS19, RPL5, or RPL11 transcripts75,78. Here, TP53 is linked to Diamond-Blackfan anemia.