PDX1 and familial pancreatic carcinoma: To investigate the role of Hmga2 in PDAC, we first confirmed Hmga2 expression in the carcinoma stage of pancreatic cancer tissue isolated from the well-established autochthonous KrasLSL-G12D/+;p53LSL-R172H/+;Rosa26LSL-tdTomato/+;Pdx1-Cre (KP172CT) mouse model of PDAC (Fig. 1a, Supplementary Fig. S1a).