Furthermore, histological analysis of the tumours from gemcitabine treated KPKOC;Hmga2+/+ and KPKOC;Hmga2CK/CK mice uncovered comparable histology, with complete destruction of normal pancreatic architecture and development of undifferentiated and anaplastic PDAC (Fig. 3c,d). The gene discussed is HMGA2; the disease is neoplasm.