CCN6 and cancer: Amongst the 71 mutated MSI target genes in which the PTC-mRNAs were expected to be down-regulated by NMD, we identified 15 aberrant transcripts encoding mutant proteins with putative retained tumor suppressor functions, including PDS5B, WISP3, and PANK1. The PDS5B mutant protein, for example, retains all the regions and residues involved in the recruitment and release of cohesin and other partners during mitosis, suggesting it has conserved tumor suppressor activity in MSI cancer cells33.