CASP3 and hydrops fetalis: Importantly, Sandalore® treatment retarded spontaneous HF regression (catagen development)26,27 ex vivo (Fig. 1b) and significantly reduced hair matrix keratinocyte apoptosis, as shown by quantitative (immuno-)histomorphometry for TUNEL+ (Fig. 1c) or cleaved caspase 3+ cells (Supplementary Fig. 1a) in the hair matrix.