Because CD4+ T-cell responses are largely programmed by APCs, we employed the naive T-cell transfer model of colitis (i.e., adoptive transfer of naive CD4+ T cells to Rag1−/− hosts) to test whether, in the absence of acute bacterial challenge, deficiency of Alpk1 in APCs could influence the phenotype of expanding T cells. Here, ALPK1 is linked to colitis.