Notably, ALPK1 expression in IBD tissue was closely correlated with that of Th1-related cytokines (IFNG, IL12A, IL12B, and CXCL10) but not Th2 or Th17 cytokines (IL4, IL13, and IL17A) (Fig. 6b). Here, CXCL10 is linked to inflammatory bowel disease.