Consistent with prior observations of the Hiccs and Cdcs1 loci3 (Supplementary Fig. 1-2), irradiated WT mice reconstituted with Alpk1−/− bone marrow developed more severe Hh + anti-IL-10R-induced colitis in comparison to those that received WT bone marrow (Fig. 4a–c). This evidence concerns the gene IL10RA and colitis.