SOX2 and central nervous system cancer: As expected, immunofluorescence staining showed high percentages of SOX2-positive (SOX2+) and Olig2+ tumor cells (stem cell markers) within tumor tissues from the mock infection group (Fig. 2E; see also Fig. S3A, bottom panels), whereas the proportions of SOX2+ and Olig2+ glioma cells were significantly lower in tumor tissues from the ZIKV-LAV-treated mice (Fig. 2E; see also Fig. S3A, top panels).