The list contains RUNX3 (a transcription factor that functions as a tumor repressor (Chi et al. 2017), HCN1 (that codes for a proton channel that regulates the normal brain rhythmic activity (Pan et al. 2015), and the fork-head transcription factors FOXD3 (involved in cell pluripotency and reported as tumor suppressor; Li et al. 2017), and FOXA1 (reported as tumor progressor in several human cancers; Lin et al. 2018). The gene discussed is RUNX3; the disease is cancer.