Another candidate to mediate effects of early life experiences on AD vulnerability/resilience is EGR1 (also commonly referred to as Zif268, NGFI-A, or KROX-24), a transcription factor critically involved in processes underlying neuronal activity, from neurotransmission and synaptic plasticity to higher order processes such as learning and memory, and to the response to emotional stress and reward [164–169]. This evidence concerns the gene EGR1 and Alzheimer disease.