Cases FTD-tau1 (frontotemporal dementia, tau variant) and AD1 (AD Braak VI) had significantly more seeding from frontal cortex microglia CM compared to microglia isolated from the cerebellum, an area spared from tau pathology in the cases examined here (Fig. 5) as measured by two-way ANOVA and Bonferroni post-hoc (p < 0.01). This evidence concerns the gene MAPT and Alzheimer disease.