ACE2 and type 2 diabetes mellitus: As shown in Table 1, ACE2 SNPs rs1978124 (P < 0.001), rs2048683 (P < 0.001), rs2074192 (P < 0.001), rs233575 (P < 0.001), rs4240157 (P < 0.001), rs4646156 (P < 0.001), rs4646188 (P < 0.001) and rs879922 (P = 0.005) were significantly associated with T2D except rs2235306, rs2285666, rs4646142, rs4830542 and rs6632677 (all P > 0.05, see Additional file 1: Table S4).