To investigate if alterations in LSD1 activity rather than gene expression alone can be used for prognostication in SHH patients, we performed a clustering of SHH tumor samples using gene expression data of known LSD1 target genes in the brain along with target genes of its interacting partner-REST, the REST and LSD1-specific deubiquitylase (DUB) USP7, and genes known to contribute to MB metastasis. The gene discussed is REST; the disease is neoplasm.