P2RY12 and atrial fibrillation: The results of the 2017 RE-DUAL-PCI trial [36] demonstrated that, among AF patients who underwent PCI, the risk of bleeding was lower for those receiving dabigatran and a P2Y12 inhibitor (clopidogrel or ticagrelor) than for those receiving ‘triple therapy’ (VKA, aspirin, and P2Y12 inhibitor), without a decrease of thromboembolic events (even if eGFR < 30 mL/min/1.73 m2 was an exclusion criterion and an “eGFR threshold” for “history of renal disease” was not specified).