CST3 and chronic myelogenous leukemia, BCR-ABL1 positive: Tocovid significantly reduced serum creatinine compared to placebo (−11.28 umol/L ± 4.31, p = 0.014) despite adjustment for baseline value of serum creatinine, HbA1c, SBP, DBP, age, weight, AGE, CML, sRAGE, and Cystatin C. The result suggests that Tocovid prevented the progression of renal impairment by stabilizing serum creatinine when compared to placebo.