The present study aimed to establish a correlation between diabetic nephropathy with HbA1c, blood pressure, AGE, sRAGE, Nε-CML, and Cystatin C. The second aim is to investigate whether high-dose Tocovid will have an effect on diabetic nephropathy assessed by UACR, serum creatinine, and eGFR. The gene discussed is CST3; the disease is diabetic kidney disease.