IGFBP5 and cancer: Among the most highly up-regulated proteins, we selected for further study Carboxypeptidase E (CBPE), which has been implicated in cell proliferation and survival in other cancer types [15,16], as well as platelet-derived growth factor D (PDGFD), epidermal growth factor (EGF)-containing fibulin-like extracellular matrix protein-1 (FBLN3), insulin-like growth factor binding protein-5 (IBP5) and insulin-like growth factor binding protein-7 (IBP7), respectively associated to growth factor-signaling pathways through PDGF, EGF, and insulin-like growth (IGF) receptors [17,18,19].