For instance, higher level of signal transducer and activator of transcription 3 (STAT3)-mediated transcription of miR-214 was associated with ulcerative colitis (UC) and progression to colitis-associated colon cancer (CAC), which induced by interleukin-6 (IL-6), increases phosphorylation of AKT, and activates NF-κB through direct repression of PTEN, PDZ and LIM domain 2 (PDLIM2) [55]. Here, STAT3 is linked to malignant colon neoplasm.