In addition, miR-96 also plays a drug-sensitizing role via deregulating the anti-apoptotic regulator X-linked inhibitor of apoptosis (XIAP) and the p53 stability regulator ubiquitin-conjugating enzyme E2N (UBE2N), resulting in a synergy with cell-cycle-dependent drugs 5-FU and apoptotic cell death in CRC cells [33]. Here, UBE2N is linked to colorectal carcinoma.