MDM2 and neoplasm: MiR-194 was frequently decreased in CRC, with this level closely associated with the overall survival of patients and obviously associated with tumor size, as well as the tumor node metastasis (TNM) stage that is involved with cell proliferation, colony formation, promoted G0/G1 arrest, and induced cell apoptosis through negative regulation of the MAP4K4/c-Jun/MDM2 or PDK1/AKT2/XIAP signaling pathway, and acts as an tumor inhibitor in CRC, but not related to lymphatic invasion and distant metastasis [65,66].