PTEN and colorectal carcinoma: In CRC, miR-92a, significantly up-regulated in the tissues or cell lines, led to down-regulation of E-cadherin and up-regulation of β-catenin and vimentin, involved in the regulation of epithelial-to-mesenchymal transition (EMT) via an interaction with its target, PTEN, through the PTEN/PI3K/Akt pathway [29].