MiR-182 and miR-503 undergo sequential up-regulation and contribute to the malignant transformation of colon adenoma to adenocarcinoma by cooperatively down-regulating the tumor suppressor F-Box and WD repeat domain containing 7 (FBXW7) which is the substrate recognition component of a ubiquitin ligase complex involved in cell cycle and targeted proto-oncogenes such as c-Myc and cyclin E2 [58]. Here, FBXW7 is linked to adenocarcinoma.