FBLN7 and congenital heart disease: In a novel deletion of human chromosome 2q13 associated with craniofacial malformation and congenital heart disease, fibulin-7 was identified as one of the responsible genes for the phenotype as fibulin-7 knockdown in the zebrafish model leads to cardiac and craniofacial defects as well as reduced cartilage deposition in the pharyngeal arches and impaired branchial arch development [125].