TGFB1 and aortic aneurysm: The regulatory role of fibulin-4 in TGF-β signaling has been studied in human cutis laxa [93,139] and in the mouse models with deficient or reduced fibulin-4 causing upregulation of TGF-β and defect in elastic tissue formation, resulting in aortic aneurysm and arterial tortuosity [95,96].