Nevertheless, immunolocalisation studies of human atherosclerotic lesions strongly support a role for TGFβ in the pathogenesis of CAD, showing high levels of TGFβ1 and TGFβ3 in SMCs and macrophage-derived foam cells in early fatty streak lesions, co-localising with TβRII and ALK5 [13]. Here, TGFB1 is linked to coronary artery disorder.