For example, functional polymorphisms in the promoter, signal peptide sequence and coding sequence of the TGFβ1 gene are associated with increased risk of myocardial infarction [64,65]) and stroke [66]; meta-analyses have also shown an association between these polymorphisms and CAD [[67], [68], [69], [70]]. Here, TGFB1 is linked to coronary artery disorder.