Moreover, levels of TNF-α are strongly correlated with adiposity anddiminished vasodilation in resistance arteries of rats, and IL-6 levels areproportional to adiposity whose elevations result in direct impairments ofendothelial function.31 On theother hand, the decreased adiponectin levels are associated with dyslipidemia andcardiovascular diseases. The gene discussed is ADIPOQ; the disease is metabolic syndrome.