Besides that, leptin acts as a powerful sympathostimulator,associated with increased BP and tachycardia, which consequently contributes toobesity-related hypertension and kidney damage.24 Furthermore, a study has supported that the LAR is morebeneficial than either alone for the diagnosis of MetS.25 The use of LAR has the potential to assess insulinsensitivity and MetS in the non-fasting state, since the difference betweenadiponectin and leptin tends to be small in the fasting versuspostprandial state.26 Our studyshowed that LAR was independently associated with the presence of MetS. The gene discussed is LEP; the disease is Nephropathy.