In a multiple regression analysis, MA (odds ratio =8.51; p = 0.01), leptin/adiponectin ratio (LAR) (odds ratio = 4.13; p =0.01) and RHTN (odds ratio = 3.75; p = 0.03) were independently associatedwith the presence of MetS apart from potential confounders. The gene discussed is LEP; the disease is metabolic syndrome.