Previous studies have shown an inverse association between adiponectinlevels and low-grade albuminuria in essential19 and resistant hypertensive patients.20,21 Similarly in experimental studies,adiponectin knockout rats have higher levels of albuminuria (twice above normalvalues), and after replacement of the protein, albuminuria returned to its normallevels.22 Hyperleptinemiais also an independent risk factor for coronary artery disease 23 and strong predictor of acutemyocardial infarction. The gene discussed is ADIPOQ; the disease is coronary artery disorder.