Our finding of increased MA in hypertensive patients with MetS is supported byprevious studies.13 The commonunderlying mechanisms that may explain increased MA in patients with MetS includefactors such as: (i) overactivation of the renin-angiotensin system; (ii) increasein oxidative stress and (iii) inflammation.15 In addition, the presence of MA may affect reflectprogressive endothelial and vascular dysfunction.16 It is worth to mention that we found no differencein BP levels between the groups. This evidence concerns the gene REN and metabolic syndrome.