Therefore, to determine if the suppression of yata expression can rescue the phenotypes of the Drosophila model of Alzheimer's disease, we tried to utilize RNAi-mediated partial knockdown of yata. We utilized the Gal4-UAS system [45] and knocked down yata expression by the combination of UAS-yata-RNAi with the ubiquitous actin5C-Gal4 driver. This evidence concerns the gene LGALS4 and early-onset autosomal dominant Alzheimer disease.