Results indicated sepsis mortality was not different between WT and CD43-/- mice in the absence of Treg (p = 0.85, n = 10 mice/group) (Fig 12D), demonstrating that depletion of CD25+ Treg eliminated the survival disadvantage that we had previously observed in CD43-/- relative to WT septic hosts (Fig 2). This evidence concerns the gene SPN and Sepsis.