INS and type 2 diabetes mellitus: Taking into consideration the recommendations of the consensus guidelines, the mean HbA1c in this study was high prior to insulin initiation (9.4% [79.2 mmol/mol]), especially compared with that reported for the overall T2D cohort in the CoDiC database (irrespective of the treatment received), in which mean HbA1c improved from 7.41% (57.5 mmol/mol) in 2001 to 7.06% (53.7 mmol/mol) in 2012 [18].