HSPA5 and neoplasm: Wang et al. described a 64Cu-labelled anti-GRP78 monoclonal antibody, MAb159, which binds to GRP78 with an affinity in the low nanomolar range (Kd = 1.7 nM) [43, 44] Although only modest tumour uptake was observed in GRP78-overexpressing BxPC-3 xenografts in mice (18 ± 1.0%ID/g at 48 h after injection; Fig. 3), no uptake above EPR was observed for a 64Cu-labelled nonspecific isotype control antibody, suggesting that labelled antibodies such as this one may have translational potential.