The chronological order in the PD/DLB mouse model, in which pSer46-MARCKS precedes histologic aggregate formation, was analogous to our previous observation in AD model mice, in which pSer46-MARCKS was detected in the cytoplasm and neurites of neurons before staining of extracellular Aβ aggregates was apparent (Fujita et al., 2016). This evidence concerns the gene MARCKS and Parkinson disease.