GBA1 and Lewy body dementia: In this study, we detected similar phosphorylation of MARCKS at Ser46 in BAC-Tg mice overexpressing human normal α-synuclein (α-Syn) in the glucocerebrosidase (GBA)-heterozygous-knockout (KO) background (human α-Syn-BAC-Tg/GBA-hetero-KO mice), as well as in human DLB patients.