Immunoprecipitation by anti–pSer46-MARCKS coprecipitated pSer129-α-Syn from brain samples (whole cerebral cortex) of α-Syn-BAC-Tg/GBA-hetero-KO mice at 24 months of age (Fig. 7A) and from those of human DLB patients (Fig. 7B). This evidence concerns the gene GBA1 and Lewy body dementia.