MARCKS and Alzheimer disease: The chronological order in the PD/DLB mouse model, in which pSer46-MARCKS precedes histologic aggregate formation, was analogous to our previous observation in AD model mice, in which pSer46-MARCKS was detected in the cytoplasm and neurites of neurons before staining of extracellular Aβ aggregates was apparent (Fujita et al., 2016).