P2RY10 and atherosclerosis: Curtiss et al. examined the TRIF mutated gene (Lps2) in LDLR−/− mice and found that LDLR−/− mice with lack-of-function mutations in TRIF (Lps2) were significantly protected from atherosclerosis, assessed by heart sinus and aorta lesion size quantifications, and these mice displayed fewer lesional macrophages [52].