However, many cancer studies have assessed the involvement of the RelA subunit alone or in combination with other subunits like RelB, NF-κB2, c-Rel, etc. Nonetheless, outcome of the studies that methodically examined RelA and p50 have reported altered expression with an impact on recurrence and survival (Jenkins et al., 2007; Annunziata et al., 2010; Wu et al., 2015). The gene discussed is REL; the disease is cancer.