TNFSF10 and neoplasm: And another mechanism suggests that TNFRSF10C can inhibit apoptosis induction (Murphy, Perry & Lawler, 2008) by competing the binding of TRAIL with TNFRSF10A and TNFRSF10B. TNFRSF10C’s down regulation will reduce its resistance to apoptosis and represent a protective response to tumor progression (Cheng et al., 2009), which is contrary to our observation.