However, the blood VEGF levels in patients with MDD were significantly higher than those in the healthy controls, and the difference was negatively correlated with the mean age [29].VEGF and VEGFR2 increased significantly in the prefrontal cortex after chronic restraint stress, and there was a tendency towards increased serum VEGF protein expression after both acute and chronic restraint stress [30]. The gene discussed is KDR; the disease is major depressive disorder.