CSF2 and neoplasm: Additionally, they neutralize tumor-induced immunosuppression, at least in vitro [22]. In vivo both, extracts and purified MLs, increased the number of leucocytes and granulocytes and enhanced the blood level of granulocyte-macrophage colony stimulating factor (GM-CSF), interferon (IFN)-γ, and interleukin (IL)-5 [23].