In vitro, ISCADOR Qu as well as Aviscumine and native ML-1 enforced the priming and expansion of tumor-specific T-cells and, at least partially, boosted the T-cell-mediated killing of glioma cells, being the ISCADOR Qu-mediated immunosupporting effects superior to that of Aviscumine or native ML-1 (Figure 1). Here, ATP8A2 is linked to central nervous system cancer.