What is interesting, BSYZ downregulated the expression of NLRP3, caspase-1, ASC, pro- IL-1β, and IL-1β both in MPTP-induced mice and MPP+ stimulated microglia in vitro, confirming BSYZ is effective in inhibiting the NLRP3 activation in PD models both in vivo and in vitro and BSYZ may protect against dopaminergic neuronal injuries via deactivation of microglia NLRP3 inflammasome. This evidence concerns the gene IL1B and Parkinson disease.