Our results confirmed that CSCs-exosomes increased the expression of Bcl2, TGFβ1, NFκB, MMP9, and VEGF genes; the expression of TGFβ1, P13K, and ERK proteins; the immunostaining of PCNA; and the serum level of TGFβ1, but decreased Bax, p53, and TIMP1 mRNA levels in livers of HCC rats as compared to HCC rats injected by PBS. The gene discussed is TP53; the disease is hepatocellular carcinoma.