TGFB1 and hepatocellular carcinoma: Similarly, anti-HCC miR148a and miR125b exert inhibitory effects on epithelial mesenchymal transition (EMT) and CSC-like phenotypes by targeting TGFβ1, which is a potent stimulator for EMT in the tumor microenvironment and induces the transformation of liver stem cells into CSCs in HCC [60].